Mitotic Motors: Kinesin-5 Takes a Brake
نویسندگان
چکیده
A kinesin-5-dependent 'sliding filament' mechanism is commonly used to actively push apart the poles during mitotic spindle assembly and elongation, but a recent study now shows that, in C. elegans, kinesin-5 is deployed as a brake to slow down spindle-pole separation.
منابع مشابه
Kinesin-5 acts as a brake in anaphase spindle elongation
Bipolar kinesin-5 motors, essential in diverse organisms, can generate positive sliding forces between overlapped interpolar microtubules to push mitotic spindle poles apart. BMK-1, the sole Caenorhabditis elegans kinesin-5, is not essential. We have determined, by tracking pole movements in bmk-1 mutant C. elegans embryos, that BMK-1 actually resists pole separation during anaphase. This provi...
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عنوان ژورنال:
- Current Biology
دوره 17 شماره
صفحات -
تاریخ انتشار 2007